It is unclear how SDF 1

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based cell attraction versus repulsion establishes the divergent signalling profiles suggested by the inhibitor experiments outlined above.cheap nfl jerseys The simplest explanation may depend on differences observed in G protein coupled receptor signalling when emanating from the plasma membrane versus receptor/ligand complexes in the endocytic vesicles.21, 22 If, as we suggest here, the critical step mediating SDF 1 cell repulsion is SDF 1/CXCR4 dimerization and internalization, then the process of repulsion by a chemokine would require unique signals from receptor complexes in endocytic vesicles. And these unique signals might be associated with a special pattern of response to kinase inhibitors, as seen in the Poznansky experiment..

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